ResMed sells both machines in the US. The AirSense 11 is the newer one, but the AirSense 10 is still on ResMed’s own shop. Here’s what differs, taken from ResMed’s US user guides (AirSense 11, AirSense 10).
Side by side
| AirSense 11 AutoSet | AirSense 10 AutoSet | |
|---|---|---|
| Pressure range | 4–20 cmH₂O | 4–20 cmH₂O |
| Models | AutoSet, AutoSet for Her, Elite, CPAP | AutoSet, AutoSet for Her, Elite, CPAP |
| Ramp | Off, 5–45 min, or Auto | Off, 5–45 min, or Auto |
| Humidity level | Off, 1–8 | Off, 1–8 |
| Water tub | 380 mL | 380 mL |
| Sound, with humidifier | 27 dBA | 27 dBA |
| Weight | 40 oz (1,130 g) | 44 oz (1,248 g), with water tub |
| Power supply DC output | 24 V, 2.71 A (65 W) | 24 V, 3.75 A |
| Typical / peak power | 56.1 W / 73.2 W | 53 W / 104 W |
| Max supplemental oxygen | 15 L/min | 4 L/min |
| Operating altitude | Sea level to 9,870 ft | Sea level to 8,500 ft |
| Bluetooth to myAir app | Yes | No (myAir gets data via ResMed’s cloud) |
| Personal Therapy Assistant, Test Drive | Yes | No |
| FAA in-flight use | Yes | Yes |
| Design life (device) | 5 years | 5 years |
| ResMed US shop price, 13 Oct 2026 | $1,054 (standard tube), $1,096 (ClimateLineAir) | $1,008 (with ClimateLineAir) |
| cpap.com price | $1,004 (cpap.com) | not verified |
Sources: the two ResMed user guides above, the myAir user guide, and ResMed’s US shop. HHZ didn’t measure noise or power.
What’s the same
The core therapy hasn’t changed. Both AutoSet models are prescription-only auto CPAPs for obstructive sleep apnea in patients weighing more than 66 lb. Both offer AutoSet for Her mode for women with mild to moderate OSA. Both have SmartStart, Mask Fit, the same humidity scale, the same 380 mL tub and the same ramp options. Both send therapy data to your care provider wirelessly, with an SD card as the alternative.
What the AirSense 11 adds
- Bluetooth and the myAir app. ResMed’s myAir guide says Bluetooth features are only on the AirSense 11. Those include Personal Therapy Assistant (guided setup videos) and Test Drive, which introduces pressure gradually (7 and 10 cmH₂O) before your first night (myAir user guide). See myAir and OSCAR explained.
- Higher oxygen limit. 15 L/min vs 4 L/min. This matters if you need oxygen bled into your CPAP.
- Smaller power supply. 65 W vs a 3.75 A (90 W class) supply, with a lower peak draw (73.2 W vs 104 W). Typical draw is similar.
- Slightly lighter. 40 oz vs 44 oz.
What the AirSense 10 still has going for it
It’s the cheaper ResMed listing ($1,008 with heated tubing, vs $1,096 for the AirSense 11 with heated tubing on the same day). Its comfort settings are the same. If you already own one, nothing in ResMed’s guides suggests you need to upgrade for therapy reasons. ResMed lists a 5-year design life for the device, so age is a better reason to replace than features.
Who should pick which
| You are… | Pick |
|---|---|
| New to CPAP and want guided setup | AirSense 11 (Personal Therapy Assistant, Test Drive) |
| On supplemental oxygen above 4 L/min | AirSense 11 |
| Paying cash and want the lowest ResMed price | AirSense 10 |
| Replacing an AirSense 10 that’s 5+ years old | Either; AirSense 11 if you want myAir Bluetooth features |
| Mostly traveling | Consider a travel CPAP instead (travel CPAP guide) |
Settings are explained in AirSense 11 settings explained. Both need a prescription in the US. Medicare rules are in Medicare CPAP coverage, and cash costs in CPAP cost without insurance.
Verdict
Buy the AirSense 11 if you’re new to CPAP, use high-flow oxygen, or want myAir’s Bluetooth features. The AirSense 10 delivers the same pressure and comfort settings for less, so it’s a fair choice on a budget. Neither is a reason to give up a working machine early.
Related: best auto CPAP machine, APAP vs CPAP vs BiPAP, CPAP batteries and camping power.